Building a Working Brain
Individual cells in the embryonic brain of a mouse have been color-coded to identify what their job is. Green cells are ‘progenitors’ that can become several cell types. Red cells are ‘interneurons,’ cells that connect neurons in the brain to form sensory and motor circuits by inhibiting other neurons. These interneurons will migrate into the cerebral cortex as the brain matures. A new study by Debby Silver’s lab has identified a key molecular signal that controls the formation of interneurons, a finding that gives them insight into developmental brain disorders and autism spectrum disorders.