Post-doctoral fellow Anna Loksztejn of the Center for Biologically Inspired Materials created this image of aggregated insulin proteins using atomic force microscopy. Colors are used to show details of structure, giving crucial information on how misfolded proteins can be stacked into fiber-like structures called amyloids.
Human memory – taking in information, storing it and retrieving it accurately – is key to a variety of crucial decisions made in medicine or law and physical movements like dance.
Cognitive scientist Ruth Day wants to understand it better.
"I see people who are doing well but not well enough," she says. "Maybe they prescribe or dispense the wrong drug. Maybe they can't remember what they've just seen."
Or maybe a dancer twirls to the left when all the other dancers are going right.
Each pixel of this image from a DNA microarray analysis chip represents the activity of a gene found in human tumor samples. Individual patients are represented in columns, and genes are in rows. The color of each pixel shows how active a particular gene is within the tumor, and analyzing a genome this way can help physicians determine which chemotherapy treatment will work best for a given patient.
Geneticist and bioethicist Charmaine Royal PhD is an associate research professor in the Institute for Genome Sciences & Policy and the Department of African and African American Studies. She studies the interaction of genomic science and racial identity, particularly as it relates to research, healthcare, and the broader society.
<p>Using a fleet of iron-transport proteins, modeled here as little Pac-Man shapes, the pathogenic bacterium Neisseria gonorrhoeae steals iron from its human host and transports the pilfered metal (orange balls) across the space between its outer and inner membranes. Understanding how the bacterium that causes the sexually transmitted disease gonorrhea obtains this essential nutrient could be key to fighting the disease.
Hearing about the toxic mix of viruses, bacteria and air pollutants we breathe every day would make anyone want to hold their breath.
But the lungs harbor a secret weapon against those warriors of disease.
Graduate school is sometimes a good metaphor for the research process -- feeling one's way along in the dark.
But three women working in the lab of Jo Rae Wright feel like they have an expert guide on both journeys.
In addition to learning a lot about how the goopy lining of the lungs responds to the arrival of a potentially nasty pathogen called Cryptococcus neoformans without overreacting, Scarlett Geunes-Boyer has found her own way as a researcher.
The Molecular and Genomic Vascular Biology lab on the fourth floor of Duke’s gleaming Genome Sciences Research Building II is diverse in both its research questions and the people who are pursuing them.
Duke Medicine Chancellor Victor Dzau has assembled a team of researchers from Greece, China, Chile, Sri Lanka, India and the United States to work together on five projects related to heart tissue, including studies of natural chemical signals that may repair and protect heart muscle.”
One of the many seemingly magical properties of adult stem cells has been their ability to repair and renew heart muscle after a heart attack. But why and how they work is still an open question.
Several pre-clinical studies with mice have documented that adult stem cells create new cardiac muscle cells, replacing an area of the muscle damaged by the loss of oxygen during a heart attack.