Cathrine Hoyo’s first job out of university was as a statistician for health surveillance in her native Zimbabwe. But after a few years of “counting numbers of sick people,” she decided to learn more so she could do more.
A mast cell from the immune system keeps a ready supply of signaling molecules (green) so that it can sound the alarm and call other immune system cells to the fight when it detects a pathogenic invader. But the bacteria Salmonella (red) has been found to move into the mast cell and jam its ability to release these signaling molecules, effectively silencing the alarm and letting the invader spread relatively unimpeded. A Duke Medicine and Duke-National University of Singapore (Duke-NUS) team led by Soman N.
Assistant professor of biochemistry Michael Boyce and his colleagues have developed a new method for detecting one relatively short-lived but crucial cell signaling event: the attachment of a particular sugar, called GlcNAc, onto proteins inside the cell. Two protein samples are labeled through their GlcNAc sugars with green and red fluorescent dyes, and then separated on a gel.
A false color scanning electron micrograph shows infectious spores of Cryptococcus fungi (purple) decorating the surface of the specialized structure where they are produced by meiotic cell division. Airborne on wind currents, these spores are small enough to penetrate deeply into human airways to cause an initial lung infection that spreads via the bloodstream to infect the brain.
Weighing a little less than two cubes of sugar when he was born at the Duke Lemur Center in June, male mouse lemur Filbert is one of more than 40 grey mouse lemurs living at Duke. If all goes well, Filbert could live to be 10-15 years old in captivity. Grey mouse lemurs are nocturnal animals that develop dementia-like symptoms similar to human Alzheimer’s as they age.
Researchers at the Duke-NUS Graduate Medical School in Singapore captured this image of astrocytes (star-shaped glial cells of the brain) that were developed from neural stem cells of mice in a lab dish. The nuclei of the cells are stained pink and the green dye is specific to a protein that marks them as astrocytes. Astrocytes are helpers and supporters of the brain's neurons and they perform repairs after a brain injury.