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adipose cells in zebrafish pancreas

Creeping Fat

With obesity and age, fat cells invade the pancreas, where they become factors in the insulin secretion process relevant to diabetes and in the inflammation that leads to pancreatitis and pancreatic cancer. James Minchin, a post-doctoral researcher in the Department of Molecular Genetics and Microbiology made this image of lipid droplets (magenta) surrounded by fibrous collagen (green) in the pancreatic tissue of zebrafish as part of his work on genetic and environmental sources of obesity. Minchin works in the lab of John Rawls, which has pioneered the use of zebrafish as a model for investigating adipose tissue development and physiology.

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